Yes, but will only boot with an RP2350 plugged in.
So, yes as long as the device doesn’t reboot.
Which reminds me of early iPhone Jailbreaks

Post-exploitation, usbliter8 injects a custom USB request handler and stamps PWND:[usbliter8] into the device’s USB serial string. From there, an attacker can temporarily demote the SoC’s production mode or boot a raw, unsigned iBoot image with no signature checks, stepping outside Apple’s chain of trust entirely.

Highly unlikely