I had one really good game of Vampire. Lasted a couple years. We still talk about it sometimes, and its best scenes. Like how one PC saved an NPC by jumping out a 10th story window with her. Or the time they had a huge in character fight because the job they’d tried to do went sideways.
But I’ve also had a couple really bad games. There was one where they just didn’t read and retain anything from the books. One of the players on like session 4 was like “wait. How do I get more blood? Do I like… Bite people?”. My friend what do you think was happening in the other scenes when people were hunting for blood? They also didn’t retain anything about the different factions, so they didn’t really understand anyone’s motivation. It was bad. Still feel bad about it.
I ran a game in near future New York and used Google maps and street view for guidance. Worked well. None of the other players lived here, so I think the visuals helped them.