Definitely. Keep your palms high to make it easier for the pinky to reach. If you rest your palms on the keyboard, it will make it awkward to use the pinky for keys in the upper rows.

I use Linux Mint with 2 4k monitors and have never had a problem. I use an Nvidia card and I think once I installed their drivers it just worked.

They provide tools that make it easier to automate large-scale deployments of servers and applications.