There is a certain preferabillity to having things able to be decentralized enshrined like the way it has to proceed now. If a fascist gets in Office again, California et al can say let you enforce it and give you the finger and that will for the most part be the end of it

Don’t get me wrong: people will fall thru the cracks and there will be blood, but this gentile gentlemen’s agreement bullshit has to stop. The legislatures need to send 'Pubs packing and fucking enshrine actualy damn rights to make them inalienable. The right and sensible thing needs to be the only thing selling and motivating pols to for their own survival do the needful.

Whatever sense or legal rationale Row has furnishing it, it seems obvious in retrospect that Republicans play both the states snd federal rights game, so the States are on their own insulating themselves from the caprices of dissimilar populations that are significantly less representative of the country (as a whole) and also basically antithetical to the entire existence of their own specific state, culturally, geographically, economically, education-wise, the works…

More kompromat. Fantastic. I wonder if thats what all this Russia.Russia.Russia obsession the GOP and its owner class is all rooted in.

Not so much for stocks, I mean like a better UI spreadsheet client that allows them to go to any period and see ledgers that are intuitively rendered and that lets them sort of experiment with the numbers so they can learn to maneuver things better. Like all their accounts, bills/recurring, paycheques, purchases. All rendered and projected or archived for easy traversal

Its like GTD: get everything out and externalized in an independant system or locus of reference and it takes most of the anxiety and human error out of it

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He should prove it by drinking some

Full disclosure: I have some unhealthty fantasies about DeSanctimonius being exorcised and renewed in the blood of the cleansing waters of Ganges river

You’re never gonna fully attnuate all the edge cases and it doesn’t really matter that some people end up being “allergic” or oversensitive or undersensitive to it. Thats what titration and medical supervision are for, not everything works for everyone.

Thats why choice and second/third/fourth line etc treatments exist. I sometimes do wonder if you did a double blind with folks and didn’t tell them, I would conjecture the hyper-extended nature of such things if that were so established could be sufficient to mitigate for individual differences in metabolic-polymorphism or whatever

It’d be cool if they offered periodic randomization of the origin country, really mix things up ;)

Gotta dispose of them like how they do the fractional mountains of drugs

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The point I’m making is, while I’m aware of people being fast or slow metabolizers, that should only factor in when it comes to active ingredient that is fully mechanically released and available for metabolism.

It cannot metabolize that which has not either been a) mechanically released or b) that which is pharmacodynamically inertt since it requires cleaving off the other binding substance (like l-lysine in Vyvanse) before the underlying active drug can be mechanically available to metabolize if that makes sense.

Vyvanse cannot be injected or administered in basically any other ROA than oral like normal dex because it (lis-dexamferamine—not dextroamphetamine) is inert until it has undergone the uncleaving of lysine from the active drug. Doesn’t matter how fast one metabolizes dextro, nobody metabolizes lis as a straight stimulant, it is inert until made not so thru the blood or whatever.

Also, doesn’t that mostly apply to codeine and morphine, wasn’t aware of that extending to oxy and hydro?

I don’t worship them I simply get surprised time to time altho maybe I should read their full dissents to get a better idea

XR/Extended Release

I’m very surprised the pharmaceutical market hasn’t produced the opioid analogue to Vyvanse requiring enzymatic conversion as opposed to mechanical release -> long lasting natural extended release mechanism. Its a great idea that hasn’t seemed to expand to many other therapeutic agents

Do you honestly believe folks like Jackson are equivalent to people like Thomas/Alito beyond their legal pedigree? You think she wants what they do?

Kagan, Jackson, Sotomayor are usually referred to as the liberal justices, aren’t they? Not sure whatchu getting at?

Also, why are you referring to them as Mullahs, they’re not religious teachers, any of them

But why are the liberal justices falling for it?

[old AIPAC name] He owes me money!

—AIPAC

Wanna talk about it, Sport 🥸

Is there a more comprehensive overview of this or can you expand on if not using a VPN is better?

Something, something, fingerprinting, logging in to identifiable services etc?

In its current form its already nothing, its sets the price tag at $6 billion to addict the nation and start nouveau Opium wars and still get to keep a commi$h and get out of jail free for their service

Again $6 billion is nothing, thats $120 million per 1/50 states, how much is even gonna go to each survivor or does the government annex it all basically, add it to the pork barrel to be distributed amongst their “tru$ted” partners/affiliates?