I do think their muscle would still be significantly reduced by the hormones, but the older someone is the more their body is “set in place.” This means any changes will take longer to occur and they may not happen to the degree that they would have if they started younger. So someone starting mid 20s - 30s likely won’t have skeletal changes, since that part of their body has already finished growing. (Someone starting as a young teen definitely will have skeletal changes though.)
I love the type of gameplay that the Sims (specifically building and character creation, other stuff is boring af) has but it sucks so much to play because it’s so limited unless you spend thousands on all the dlc. I am a game dev (well, I call myself that but I’ve never released anything cuz I’m too busy with finishing up college rn) and I really want to make a life sim game one day. I’ve seen plenty of indie life sims fail unfortunately, but I’m still going to try anyways. I have a few ideas I haven’t seen anyone else do. So many of these games fail that I’m not afraid to try something a bit crazy and hope it sticks.