I saw in your other comment that you were using Gnome. A lot of people like it, but Gnome wouldn’t be my recommendation.
I use a multi-monitor setup not that different from yours, and KDE handles it swimmingly. I also have an Nvidia card and I’m using X.org. I probably could use Wayland, but I’m in no rush.
If you really want to stay with a GTK desktop, then XFCE is excellent also. Budgie too.
I saw in your other comment that you were using Gnome. A lot of people like it, but Gnome wouldn’t be my recommendation.
I use a multi-monitor setup not that different from yours, and KDE handles it swimmingly. I also have an Nvidia card and I’m using X.org. I probably could use Wayland, but I’m in no rush.
If you really want to stay with a GTK desktop, then XFCE is excellent also. Budgie too.